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The results suggest a lower clearance of Tadalafil in patients with pulmonary hypertension compared to healthy volunteers. In subjects with end-stage renal disease on hemodialysis, fix Erectile Dysfunction was a two-fold increase in C max and 2. Exposure to total methylcatechol unconjugated plus glucuronide was 2- to 4-fold higher in subjects with renal impairment, compared to those with normal renal function.

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