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After taking a single tablet, some of the active ingredient of Cialis remains in your body for more than 2 days. active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. The effect of PDE5 inhibition on Sildenafil Citrate concentration in reasons of ED corpus cavernosum and pulmonary arteries is also observed in the smooth muscle of the prostate, the bladder and their vascular supply.
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